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ea0029p1352 | Pituitary Basic | ICEECE2012

Effects of the combined treatment with AMPK activator and somatostatin-14 on hormone secretion and cell proliferation in cultured GH-secreting pituitary tumor cells

Tulipano G. , Faggi L. , Losa M. , Mortini P. , Spinello M. , Cocchi D. , Giustina A.

AMP-activated protein kinase (AMPK) activation decreased GH release and intracellular GH storage in rat pituitary cell cultures and reduced cell proliferation in rat pituitary adenomatous cells (GH3) cultures.We investigated the effects of the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) as compared to somatostatin-14 on cell viability (MTT assay after 48-h) and GH secretion (over 24 h) in 16 human GH-secreting pituitary adenomas ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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